Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC032
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-10 08:15
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 2x1/2 Old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.65 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.65 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 17, 'TP': 22, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 2, 'TN': 2, 'TP': 40, 'FP': 28}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.792
timePerCircleCoV 0.0450868
timePerCircleSlope 0.00393437
meanError 1.9383
tremorFreq 6.83594
tremorRelPower 24.2621
tremorGyroAmpMean 0.0109512
tremorGyroAmpSlope 5.57162e-05
tremorGyroAmpCoV 0.367929
tremorCoordAmpMean 0.0422628
tremorCoordAmpSlope 0.0044794
tremorCoordAmpCoV 0.395703
tremorAccAmpMean 0.0175042
tremorAccAmpSlope 0.000332569
tremorAccAmpCoV 0.296156
tremorPcRelVar 0.589199
tremorPcX -0.959339
tremorPcY -0.282255

Circle Segment 1

Duration 5.8 s, Accuracy Estimate 4.606 (lower is better)

Circle Segment 2

Duration 6.0 s, Accuracy Estimate 1.557 (lower is better)

Circle Segment 3

Duration 5.68 s, Accuracy Estimate 1.488 (lower is better)

Circle Segment 4

Duration 5.72 s, Accuracy Estimate 1.458 (lower is better)

Circle Segment 5

Duration 5.4 s, Accuracy Estimate 1.98 (lower is better)

Circle Segment 6

Duration 5.44 s, Accuracy Estimate 1.633 (lower is better)

Circle Segment 7

Duration 5.76 s, Accuracy Estimate 1.55 (lower is better)

Circle Segment 8

Duration 6.12 s, Accuracy Estimate 1.255 (lower is better)

Circle Segment 9

Duration 6.2 s, Accuracy Estimate 1.617 (lower is better)

Circle Segment 10

Duration 5.8 s, Accuracy Estimate 2.238 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 18.972
timePerSpiralCoV 0.0942161
timePerSpiralSlope -0.0141197
meanError 2.01835
tremorFreq 6.64062
tremorRelPower 23.4384
tremorGyroAmpMean 0.0124072
tremorGyroAmpSlope 0.00153226
tremorGyroAmpCoV 0.310517
tremorCoordAmpMean 0.0414071
tremorCoordAmpSlope 0.00151741
tremorCoordAmpCoV 0.342849
tremorAccAmpMean 0.0201549
tremorAccAmpSlope 0.00200461
tremorAccAmpCoV 0.339164
tremorPcRelVar 0.565109
tremorPcX -0.922376
tremorPcY -0.386292

Spiral Segment 1

Duration 19.68 s, Accuracy Estimate 1.852 (lower is better)

Spiral Segment 2

Duration 19.96 s, Accuracy Estimate 1.809 (lower is better)

Spiral Segment 3

Duration 19.56 s, Accuracy Estimate 1.8 (lower is better)

Spiral Segment 4

Duration 18.56 s, Accuracy Estimate 1.868 (lower is better)

Spiral Segment 5

Duration 21.52 s, Accuracy Estimate 2.076 (lower is better)

Spiral Segment 6

Duration 20.76 s, Accuracy Estimate 1.907 (lower is better)

Spiral Segment 7

Duration 17.0 s, Accuracy Estimate 2.366 (lower is better)

Spiral Segment 8

Duration 16.16 s, Accuracy Estimate 2.057 (lower is better)

Spiral Segment 9

Duration 16.8 s, Accuracy Estimate 2.353 (lower is better)

Spiral Segment 10

Duration 19.72 s, Accuracy Estimate 2.096 (lower is better)

Elel

eDurationMean 0.651875
eDurationStd 0.0836023
eDurationStdnorm 0.128249
eDurationMedian 0.6475
eDurationQuartdelta 0.08
eDurationQuartdeltanorm 0.123552
eDurationKurt 3.5922
eDurationTrenddiff -0.0275
eDurationTrendratio 0.958647
eWidthMean 4.31145
eWidthStd 0.811703
eWidthStdnorm 0.188267
eWidthMedian 4.3875
eWidthQuartdelta 1.1115
eWidthQuartdeltanorm 0.253333
eWidthKurt 2.18548
eWidthTrenddiff -0.351
eWidthTrendratio 0.922078
eHeightMean 8.1432
eHeightStd 1.15909
eHeightStdnorm 0.142338
eHeightMedian 8.19
eHeightQuartdelta 0.9945
eHeightQuartdeltanorm 0.121429
eHeightKurt 5.69779
eHeightTrenddiff -0.351
eHeightTrendratio 0.958333
eAspectMean 0.540944
eAspectStd 0.146143
eAspectStdnorm 0.270163
eAspectMedian 0.546667
eAspectQuartdelta 0.130891
eAspectQuartdeltanorm 0.239435
eAspectKurt 15.0151
eAspectTrenddiff -0.0276608
eAspectTrendratio 0.950649
eSlantMean -0.0772907
eSlantStd 0.252936
eSlantStdnorm -3.27253
eSlantMedian -0.11133
eSlantQuartdelta 0.196617
eSlantQuartdeltanorm -1.76608
eSlantKurt 16.1535
eSlantTrenddiff -0.0489689
eRtopMean 0.654634
eRtopStd 0.13857
eRtopStdnorm 0.211676
eRtopMedian 0.649111
eRtopQuartdelta 0.216034
eRtopQuartdeltanorm 0.332815
eRtopKurt 3.43411
eRtopTrenddiff -0.0718672
eRbotMean 0.864801
eRbotStd 0.285241
eRbotStdnorm 0.329834
eRbotMedian 0.900199
eRbotQuartdelta 0.342094
eRbotQuartdeltanorm 0.380021
eRbotKurt 4.22271
eRbotTrenddiff 0.0940434
eRrightMean 0.82861
eRrightStd 0.0874316
eRrightStdnorm 0.105516
eRrightMedian 0.821998
eRrightQuartdelta 0.132941
eRrightQuartdeltanorm 0.161728
eRrightKurt 2.63328
eRrightTrenddiff -0.0132399
eRleftMean 0.494
eRleftStd 0.105644
eRleftStdnorm 0.213855
eRleftMedian 0.503165
eRleftQuartdelta 0.133532
eRleftQuartdeltanorm 0.265384
eRleftKurt 2.73355
eRleftTrenddiff -0.00089188
lDurationMean 0.837647
lDurationStd 0.103852
lDurationStdnorm 0.12398
lDurationMedian 0.8025
lDurationQuartdelta 0.14
lDurationQuartdeltanorm 0.174455
lDurationKurt 3.24829
lDurationTrenddiff -0.125
lDurationTrendratio 0.861878
lWidthMean 4.87271
lWidthStd 0.862123
lWidthStdnorm 0.176929
lWidthMedian 4.68
lWidthQuartdelta 0.819
lWidthQuartdeltanorm 0.175
lWidthKurt 4.63306
lWidthTrenddiff 0.351
lWidthTrendratio 1.07692
lHeightMean 15.7744
lHeightStd 1.43396
lHeightStdnorm 0.0909043
lHeightMedian 15.912
lHeightQuartdelta 1.638
lHeightQuartdeltanorm 0.102941
lHeightKurt 2.93292
lHeightTrenddiff -0.117
lHeightTrendratio 0.992701
lAspectMean 0.310091
lAspectStd 0.0541439
lAspectStdnorm 0.174606
lAspectMedian 0.302693
lAspectQuartdelta 0.0551876
lAspectQuartdeltanorm 0.182322
lAspectKurt 4.26137
lAspectTrenddiff 0.0039882
lAspectTrendratio 1.01326
lSlantMean -0.111049
lSlantStd 0.0955754
lSlantStdnorm -0.860663
lSlantMedian -0.119514
lSlantQuartdelta 0.1313
lSlantQuartdeltanorm -1.09862
lSlantKurt 2.34749
lSlantTrenddiff -0.0140961
lRtopMean 0.762529
lRtopStd 0.0865794
lRtopStdnorm 0.113542
lRtopMedian 0.763492
lRtopQuartdelta 0.140163
lRtopQuartdeltanorm 0.183582
lRtopKurt 2.07334
lRtopTrenddiff -0.0464286
lRbotMean 1.15623
lRbotStd 0.323842
lRbotStdnorm 0.280085
lRbotMedian 1.11029
lRbotQuartdelta 0.523671
lRbotQuartdeltanorm 0.471651
lRbotKurt 2.33345
lRbotTrenddiff 0.0788288
lRrightMean 0.868169
lRrightStd 0.0744355
lRrightStdnorm 0.0857385
lRrightMedian 0.879646
lRrightQuartdelta 0.0659252
lRrightQuartdeltanorm 0.0749452
lRrightKurt 4.99722
lRrightTrenddiff -0.0132473
lRleftMean 0.414144
lRleftStd 0.0956551
lRleftStdnorm 0.23097
lRleftMedian 0.397697
lRleftQuartdelta 0.12611
lRleftQuartdeltanorm 0.317101
lRleftKurt 3.17447
lRleftTrenddiff 0.0040695

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.996966
sumTouchScores 26.9181
meanMovementTime 0.727115
numTouches 27
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.919792
sumTouchScores 18.3958
meanMovementTime 0.992632
numTouches 20
undershootPercentage 5
overshootPercentage 15

ZigZag

numZigzags 5
timePerZigzagMean 16
timePerZigzagCoV 0.0419449
timePerZigzagSlope 0.002
meanError 2.39419
tremorFreq 7.22656
tremorRelPower 25.2346
tremorGyroAmpMean 0.0194837
tremorGyroAmpSlope 0.00281154
tremorGyroAmpCoV 0.323694
tremorCoordAmpMean 0.05957
tremorCoordAmpSlope 0.00255522
tremorCoordAmpCoV 0.219949
tremorAccAmpMean 0.0281511
tremorAccAmpSlope 0.00533378
tremorAccAmpCoV 0.288513
tremorPcRelVar 0.682425
tremorPcX -0.102254
tremorPcY 0.994758

ZigZag Segment 1

Duration 15.36 s, Accuracy Estimate 2.846 (lower is better)

ZigZag Segment 2

Duration 16.52 s, Accuracy Estimate 2.583 (lower is better)

ZigZag Segment 3

Duration 15.92 s, Accuracy Estimate 2.181 (lower is better)

ZigZag Segment 4

Duration 16.84 s, Accuracy Estimate 1.965 (lower is better)

ZigZag Segment 5

Duration 15.36 s, Accuracy Estimate 2.395 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.544
timePerZigzagCoV 0.025768
timePerZigzagSlope -0.0108418
zigzagHeightMean 79.0528
zigzagHeightCoV 0.0631687
zigzagHeightSlope 0.0214966
meanError 0.0306161
tremorFreq 7.51953
tremorRelPower 24.7753
tremorGyroAmpMean 0.0234946
tremorGyroAmpSlope -0.00266155
tremorGyroAmpCoV 0.388281
tremorCoordAmpMean 0.0755538
tremorCoordAmpSlope -0.0012483
tremorCoordAmpCoV 0.242286
tremorAccAmpMean 0.0427198
tremorAccAmpSlope -0.000516069
tremorAccAmpCoV 0.238243
tremorPcRelVar 0.80487
tremorPcX 0.112372
tremorPcY -0.993666

ZigZag Offset Segment 1

Duration 12.84 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 2

Duration 12.4 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 3

Duration 12.92 s, Accuracy Estimate 0.022 (lower is better)

ZigZag Offset Segment 4

Duration 12.4 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 5

Duration 12.16 s, Accuracy Estimate 0.04 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.75}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.65}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.08953564452942153}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Healthy’, ‘BM_HC_Sep22_score’: 0.6083391583015851}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6967248766672534}